Civil Services Prep

Prelims 2021 · Science and Technology · Question 66

In the context of hereditary diseases, consider the following statements:<br/>1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg.<br/>2. A child inherits mitochondrial diseases entirely from mother and not from father.<br/><br/>Which of the statements given above is/are correct?

  1. 1 only
  2. 2 only
  3. Both 1 and 2
  4. Neither 1 nor 2

Answer

Both 1 and 2

  1. Correct. Mitochondrial replacement therapy (MRT) is used to prevent transmission of defective maternal mitochondria; techniques exist before fertilization (maternal spindle transfer) and after fertilization (pronuclear transfer).

  2. Correct. Mitochondrial DNA is inherited almost entirely from the mother because the embryo’s mitochondria come from the ovum; paternal mitochondria are typically not transmitted.

Therefore, both statements are correct.

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